Orthoplex Folinic Acid 120caps

Orthoplex White Folinic Acid 120caps

Low Excipient Folate

10% off RRP at HealthMasters

Orthoplex White Folinic Acid is part of the Orthoplex White Range

Pack Size: 120 capsules

Orthoplex White Folinic Acid is Gluten Free, Egg Free, Dairy Free, Soy Protein Free

Orthoplex White Folinic Acid is Vegan Friendly, Vegetarian Friendly

Orthoplex White Folinic Acid AUST L 275078

Product Summary

Product Summary: Orthoplex White Folinic Acid

• Orthoplex White Folinic Acid provides 500μg of Folinic acid in a low excipient, vegetarian-friendly capsule.
• Orthoplex White Folinic Acid supports the normal remethylation of homocysteine back to methionine in healthy individuals.

Dose

Dose: Orthoplex White Folinic Acid

Adult Dose:

Take 1 capsule daily, or as recommended by your registered healthcare practitioner.

Indications

Indications: Orthoplex White Folinic Acid

• Folinic acid is required for some methylation reactions such as the normal conversion of homocysteine to methionine
• May help to support healthy DNA methylation and cell division
• Contains Folinic acid which is involved in the formation of red blood cells
• Contains Folinic acid which helps the body metabolise proteins

Ingredient Summary

Ingredient Summary: Orthoplex White Folinic Acid

There are several different forms of folates, including more than one active form. The most biologically active forms are Folinic Acid and methyltetrahydrofolate (MTHF), with the latter being the final step in the metabolism of folate (or the synthetic form, folic acid). However, the physiologic steps to convert folate into MTHF are numerous, and certain genetic predispositions can impede folate conversion. Folinic Acid offers an active form of folate, bypassing several metabolic steps towards MTHF production.

Folate Metabolism

Folate occurs naturally as a complex of related substances – folates – that are found in foods.18 However, food processing and preparation can destroy almost all of the naturally occurring folate, as it is highly sensitive to heat, air and light.17 Oral folates are generally available in two supplemental forms: folic acid and Folinic Acid. Although the most common supplemental form of the folates is folic acid, it only makes up 10% or less of dietary folates. The majority of folates in the diet consists of reduced folates and methyltetrahydrofolates. While folic acid is generally well absorbed, evidence suggests that reduced folates and methyltetrahydrofolates are absorbed differently.

Figure 1: Folate Metabolism Pathway

Both folate and the synthetic folic acid are ultimately converted into methyltetrahydrofolate, with a number of steps in between. Folate must be converted to dihydrofolate (DHF), then to tetrahydrofolate (THF), methylenetetrahydrofolate (METHF), and finally, to methyltetrahydrofolate (MTHF) (Figure 1). Folinic Acid bypasses the oxidation and reductions steps required to convert folate to THF.2

Absorption and utilisation of folates can be impeded by a number of factors, including a nutrient deficient diet or digestive issues. Genetic polymorphisms of a number of enzymes, including dihydrofolate reductase (DHFR) and methylenetetrahydrofolate reductate (MTHFR), can also impact folate metabolism.4, 5 DHFR converts folate to dihydrofolate. Polymorphisms of this enzyme, or inadequate levels of vitamin B3, reduce the activity of the DHFR enzymes, leading to a decrease in tetrahydrofolate (THF).

MTHFR is required for the conversion of METHF to MTHF. Polymorphisms of the MTHFR gene are the most well studied genetic influence on folate activity and can affect the activity of the enzyme. Extreme MTHFR deficiency is very rare, with only about 100 cases being reported worldwide.6

In the presence of sufficient folate derivatives, such as Folinic Acid, conversion of MRTHF to MTHF does occur.7

Folinic Acid

Folinic Acid, or formyl tetrahydrofolate (formyl-THF) is a more active form of folate, and as such, bypasses several steps in the conversion of folate to MTHF – the molecule the body uses in methylation reactions.

Following an oral dose of Folinic Acid, the majority of folates are metabolized to 5-MTHF directly during absorption in the intestine, bypassing the need for deconjugation and subsequent reduction in the liver.11 The rate of conversion of Folinic Acid to MTHF in the intestine is such that greater absorption and conversion is gained from oral doses than from IV administration.12

References available upon request

ingredients

Ingredients: Orthoplex White Folinic Acid

Excipients

Excipients: Orthoplex White Folinic Acid

Colloidal anhydrous silica, glycine, leucine, vegetable capsule (Vcaps).

Allergen Advice

Allergen Advice: Orthoplex White Folinic Acid

• Gluten Free, Egg Free, Dairy Free, Soy Protein Free
• Vegan Friendly, Vegetarian Friendly

Storage

Storage: Orthoplex White Folinic Acid

Store below 30°C in a cool, dry place, away from direct sunlight.

Warning

Warning: Orthoplex White Folinic Acid

Vitamin supplements should not replace a balanced diet.

Always read the label. Use only as directed. If symptoms persist consult your healthcare professional.

Pregnancy & Lactation

Pregnancy & Lactation: Orthoplex White Folinic Acid

Suitable in pregnancy & lactation

Orthoplex White

Orthoplex White

Orthoplex White Label is a range for clinical practitioners, developed for the increasing complexity of ailments presenting in clinic. To purchase products in the Orthoplex White Label range, patients must have a consultation with a clinical practitioner. Stockists of this range are bound by a contractual set of selling standards, ensuring the products are used correctly, and contributing to the robust integrity of the industry.

'I am impressed with the quality and effectiveness of Orthoplex White Label products. I have prescribed Orthoplex White Label products to my patients for over 30 years. Orthoplex White Label products have assisted me in successfully helping many 1000's of patients to better health.'

HealthMasters Naturopath Kevin Tresize ND

The Orthoplex White Label range was developed by nutritional biochemist Henry Osieki. Henry is an award-winning biochemist who, after years in clinic, developed the Orthoplex label Range of Naturopathic Medicines. The Orthoplex White Label range is known for being the first to market with new formulations, incorporating the latest in clinical research.

Orthoplex White Label formulations have always focused on providing the correct dosage for specific biochemical pathways, rather than just delivering the largest dose possible.

Orthoplex White Label is a practitioner range of naturopathic products and should be taken according to the recommendation of a qualified practitioner.