Designs For Health NR Supreme

Designs For Health NR Supreme

100% Nicotinamide riboside

Assists with NAD+ production and enhances NAD+ levels in the body

Size: 30 Vegetarian Capsules   Servings Per Pack: 30 serves

Designs For Health NR Supreme Summary:

Nicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body

• 100% Nicotinamide Riboside Chloride
• Contains 300 mg Nicotinamide Riboside Chloride per capsule
• Assists with NAD+ Production
• Enhances NAD+ levels in the body
• Vegan Friendly

Designs For Health NR Supreme AUST L 394330

Similar Products

The products listed below are suggestions that may be used as a substitute if the product you are looking for is unavailable.

• BioActiv HealthCare NMN - NMN (Nicotinamide Mono Nucleotide) 6-800mg per scoop
• Designs For Health NR Supreme - NR (Nicotinamide Riboside Chloride) 300mg per capsule
• RN Labs Nicotinamide Riboside NR - NR (Nicotinamide Riboside Chloride) 300mg per capsule

Note:

In the body, NR (Nicotinamide Riboside) converts to NMN (Nicotinamide Mono Nucleotide) which is then converted in the cell to Nicotinamide NAD (Adenine Dinucleotide).

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Directions

Directions: Designs For Health NR Supreme

Adults: Take one capsule daily

or as directed by your health professional.

Benefits

Benefits: Designs For Health NR Supreme

• Increases NAD+ status and replenishes the body’s NAD+ pool
• Provides nutritional support for NAD+ replenishment which can:
• Support energy production
• Support healthy aging
• Provide antioxidant support

Active Ingredients

Active Ingredients: Designs For Health NR Supreme

Excipients

Excipients: Designs For Health NR Supreme

Hydrated silica, Hypromellose, Purified water

Allergen Information

Allergen Information: Designs For Health NR Supreme

No Added: Soy, Dairy, Nuts, Eggs, Yeast, Sesame.

Free From: Colours, Flavours, Benzoates, Sulfites, Sorbates.

Vegan Friendly

Warnings

Warnings: Designs For Health NR Supreme

Not to be taken by children under 12 years old.

Not recommended for use during pregnancy or lactation.

Vitamin supplements should not replace a balanced diet.

Contains ribose which is a sugar.

Education

Education: Designs For Health NR Supreme

Background

Nicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body

Mechanism of Action

Nicotinamide (NAM) is required for the synthesis of NAD+, an essential coenzyme involved in several metabolic pathways. In fact, an estimated 200 enzymes – including dehydrogenases – require NAD and NADP as coenzymes. As an electron carrier, NAD+ is necessary for oxidative reactions that occur in the cytosol and mitochondria. Due to its capacity to extract energy from substrates, NAD+ is fundamental to cellular health. NAD+ is also required for carbohydrate oxidation during adenosine triphosphate (ATP) production.

Pharmacokinetics

Absorption:

Nicotinamide is absorbed predominantly in the small intestine via facilitated diffusion. Once in the bloodstream, nicotinamide moves across cell membranes via passive diffusion.

Metabolism to NAD+:

NR acts as a precursor in producing NAD+ via two pathways:

• The NRK1/2 Pathway

NR is phosphorylated to nicotinamide mononucleotide (NMN) by the enzyme NR kinase Nrk1. The resulting MNM is then converted to NAD+ by NMN adenylyltransferase.

• The salvage pathway

NR, Nicotinic acid (NA) or NAM is converted to NMN under the influence of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NMN is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT aka NMN transferase).

NR has the ability to maintain intracellular levels of NAD+ in the body.4 In the first human clinical trial conducted with NR, results found that blood NAD+ levels can increase up to 2.7 fold with a single oral dose of NR.

A randomised, double-blind, placebo-controlled trial consisting of 113 people receiving NR in combination with pterostilbene (NRPT) found that the group receiving NRPT at 250mg per day had significantly increased NAD+ levels to 40% over baseline.

Elimination:

The enzyme glycohydrolase transforms NAD into adenosine diphosphate-ribose and nicotinamide. The resulting nicotinamide is then released from cells for processing by the liver. Nicotinamide undergoes methylation and oxidation in the liver – its metabolites are then excreted in the urine. Much of the free nicotinamide is reabsorbed into the body via glomerular filtrate 

Figure 1: The salvage pathway

In the salvage pathway, the precursors are converted into an intermediate called nicotinamide mononucleotide (NMN) through nicotinamide phosphoribosyltransferase (NAMPT). Then NMN is converted into NAD+ via nicotinamide mononucleotide adenylyltransferase (NMNAT). NAD+ generated by this pathway is consumed by multiple enzymes including sirtuins, PARPs, and cADPR synthases.

Figure 2: The NRK1/2 Pathway.4

NRK 1/2 mediated NAD+ biosynthesis pathway. Nicotinamide riboside (NR) is metabolised by nicotinamide riboside kinase (NRK 1/2) to nicotinamide mononucleotide (NMN) and subsequently converted to NAD+ by NMN-adenylyltransferase (NMNAT) activity).