BioCeuticals Theracurmin BioActive 300mg 30 caps

BioCeuticals Theracurmin BioActive 300mg 30 caps

Highly Bioavailable Curcumin

• BioCeuticals Theracurmin BioActive is a highly bioavailable form of curcumin. One capsule provides the bioequivalence of 810mg of regular curcumin.
• Theracurmin possesses antioxidant properties as well as having an anti-inflammatory action.

BioCeuticals Theracurmin BioActive Available In Sizes: 30 capsules, 60 capsules

BioCeuticals Theracurmin BioActive has No Added Dairy, No Added Gluten, No Added Shellfish, No Added Soy Protein, Vegan Friendly, Vegetarian Friendly

BioCeuticals Theracurmin BioActive conditions associated: Joint Health, Antioxidants

Dose

Dose: BioCeuticals Theracurmin BioActive

Adults: Take 1 capsule one to six times daily or as directed by your health professional.

Features

Features: BioCeuticals Theracurmin BioActive

• Highly bioavailable curcumin. 27 times more bioavailable than regular curcumin.
• Now containing 20% more concentrated Theracurmin in a smaller and easier to swallow capsule.
• Theracurmin relieves the symptoms of mild osteoarthritis, reducing mild joint aches and pains, including the knee.
• Theracurmin decreases mild joint inflammation and swelling.
• Theracurmin posseses antioxidant properties helping to reduce free radicals formed in the body.
• Theracurmin has an anti-inflammatory action assisting in the relief of inflammation.

Ingredients

Ingredients: BioCeuticals Theracurmin BioActive

Ingredient Summary

Ingredient Summary: BioCeuticals Theracurmin BioActive

Superior bioavailability

Studies have shown that regular curcumin has very poor bioavailability, due to its poor water solubility, degradation in the gastrointestinal (GI) tract at neutral and alkaline pH, rapid metabolism to sulfate and glucuronide conjugates, and rapid systemic elimination.[1,3,4] This makes it difficult to reach sufficient systemic levels to achieve significant clinical results. Theracurmin is an advanced curcumin product featuring a patented manufacturing technique that increases the bioavailability of curcumin. This preparation reduces the particle size of curcumin and suspends it in a unique matrix, dramatically increasing its solubility and absorption.[1]

Clinical research has demonstrated that Theracurmin has at least 27 times increased bioavailability than regular curcumin powder, and has enhanced gastrointestinal absorption as a result of colloidal dispersion.[1,3] It reaches peak plasma levels within one hour of ingestion and continues to be detected at significantly high concentrations in plasma at 24 hours post a single dose.[1] The plasma concentrations of curcumin are shown to be significantly higher at the Theracurmin (30mg of curcumin) dose level than at the regular curcumin powder 30mg dose.[1] Theracurmin features a reduced particle size of curcumin suspended in a natural matrix, which dramatically increases its solubility and absorption.[1] Dispersed with minuscule colloidal particles, Theracurmin is highly soluble in water, which therefore makes it highly bioavailable. It remains stably dispersed even after 28 days, whereas research shows curcumin powder begins to precipitate after one hour.[1]

Anti-inflammatory effects

One of the mechanisms of curcumin may be associated with the inhibition of nuclear factor-kappa beta (NF-kB), which is pivotal in the regulation of inflammation.[3,5] Curcumin may also be a dual inhibitor of the arachidonic acid cascade, downregulating cyclooxygenase-2 (COX-2), lipoxygenase (LOX), arachidonic acid and interleukin activity; an inhibitor of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL) -1, -2, -6, -8, and -12;6,7 and help lower circulating levels of C-reactive protein (CRP).[8]

Antioxidant

Both turmeric and curcumin have potent antioxidant properties.[5] Curcumin exerts its antioxidant effects via multiple mechanisms such as scavenging of free radicals including reactive oxygen (ROS) and nitrogen species (RNS), regulates specific enzymes that neutralise free radicals and also has the ability to stop ROS-generating enzymes like cyclooxygenase and lipoxygenase.[10] Additionally, there is a direct link between oxidative stress and inflammation, where both oxidative stress and inflammation can stimulate each other.[10]

Warnings

Warnings: BioCeuticals Theracurmin BioActive

Contains maltose.

If symptoms persist, talk to your health professional.

If you have any pre-existing conditions, are on any medications, always talk to your health professional before use.

Some products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.

References

References: BioCeuticals Theracurmin BioActive

[1] Sasaki H, Sunagawa Y, Takahashi K, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull 2011;34(5):660-665.
[2] Kanai M, Yoshihiko O, Kazunori O, et al. A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients. Cancer Chemother Pharmacol 2013;69:54-70.
[3] Shimatsu A, Kakeya H, Imaizumi A, et al. Clinical application of “curcumin”, a multi-functional substance. Anti-Aging Medicine 2012;9(1):45-51.
[4] Munjal B, Pawar Y, Patel SB, et al. Comparitive oral bioavailability advantage from curcumin formulations. Drug Deliv and Transl Res 2011;1:322-331.
[5] Braun L, Cohen M. Herbs & natural supplements, an evidence based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.
[6] Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev 2009;14(2):141-153.
[7] Curcumin. Micronutrient Information Center, Linus Pauling Institute 2009, http://lpi.oregonstate.edu/infocenter/phytochemicals/curcumin/
[8] Sahebkar A. Are curcuminoids effective C-reative protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother Res 2013. Wiley online library: 10.1002/ptr.5045
[9] Turmeric. Natural Medicines Comprehensive Database. Viewed 30 Aug 2013, www.naturaldatabase.com

[10] Hewlings SJ, Kalman DS. Curcumin: A review of it's effects on human health. Foods 2017;6(10):92.